Takuji Shirasawa Selected Research

hemoglobin Presbyterian

11/2005	Beneficial effect of transfusion with low-affinity red blood cells in endotoxemia.
10/2003	The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Presbyterian hemoglobinopathy.
7/2002	Model mice for Presbyterian hemoglobinopathy (Asn(beta108)-->Lys) confer hemolytic anemia with altered oxygen affinity and instability of Hb.

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Takuji Shirasawa Research Topics

Disease

23	Alzheimer Disease (Alzheimer's Disease) 01/2012 - 05/2002
5	Hypoxia (Hypoxemia) 06/2013 - 10/2003
4	Amyloid Plaque 01/2011 - 05/2002
4	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2009 - 05/2002
3	Obesity 01/2022 - 07/2009
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2014 - 11/2009
3	Insulin Resistance 01/2013 - 01/2008
3	Cognitive Dysfunction 01/2012 - 05/2011
3	Atherosclerosis 02/2011 - 03/2007
2	Inflammation (Inflammations) 01/2022 - 12/2011
2	Hyperglycemia 11/2015 - 12/2012
2	Osteoporosis 03/2015 - 11/2011
2	Brain Diseases (Brain Disorder) 01/2015 - 07/2010
2	Dry Eye Syndromes (Dry Eye Syndrome) 01/2014 - 11/2013
2	Hypercapnia 06/2013 - 10/2003
2	Atrophy 05/2012 - 05/2009
2	Memory Disorders (Memory Loss) 01/2012 - 12/2011
2	Macular Degeneration (Age-Related Maculopathy) 12/2011 - 07/2006
2	Ischemia 04/2011 - 02/2008
2	Neoplasms (Cancer) 02/2011 - 02/2011
2	Liver Diseases (Liver Disease) 01/2010 - 10/2006
2	Mitochondrial Diseases (Mitochondrial Disease) 12/2008 - 05/2008
2	Heart Failure 08/2008 - 11/2006
2	Retinal Degeneration 05/2008 - 07/2006
2	Hemoglobinopathies 10/2003 - 07/2002
1	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 11/2017
1	Pain (Aches) 01/2017
1	Osteoarthritis 06/2015
1	Bone Resorption 03/2015
1	Perinatal Death 01/2015
1	Albuminuria 12/2012
1	Diabetic Nephropathies (Diabetic Nephropathy) 12/2012
1	Fibrosis (Cirrhosis) 05/2012
1	Hyperinsulinism (Hyperinsulinemia) 05/2011
1	Diabetes Mellitus 05/2011
1	Virus Diseases (Viral Diseases) 02/2011
1	Human Influenza (Influenza) 02/2011
1	Dementia (Dementias) 01/2011
1	Gliosis 07/2010
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 06/2010
1	Cataract (Cataracts) 06/2010
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 03/2010

Drug/Important Bio-Agent (IBA)

11	Amyloid (Amyloid Fibrils)IBA 01/2012 - 11/2002
11	Amyloid beta-PeptidesIBA 07/2010 - 05/2002
8	Superoxides (Superoxide)IBA 06/2015 - 11/2006
8	Superoxide DismutaseIBA 01/2014 - 11/2009
8	Proteins (Proteins, Gene)FDA Link 01/2012 - 08/2002
6	Peptides (Polypeptides)IBA 07/2010 - 05/2002
5	Hemoglobins (Hemoglobin)IBA 06/2013 - 07/2002
4	AntioxidantsIBA 01/2022 - 11/2009
4	Oxygen (Dioxygen)IBA 08/2008 - 07/2002
4	Presenilin-1IBA 12/2006 - 06/2003
3	Insulin ReceptorIBA 11/2015 - 04/2005
3	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2011 - 10/2006
3	hemoglobin PresbyterianIBA 11/2005 - 07/2002
3	Isoaspartic Acid (Isoaspartate)IBA 09/2005 - 08/2002
2	superoxide dismutase 2IBA 01/2022 - 01/2015
2	CytokinesIBA 12/2012 - 03/2007
2	ZincIBA 12/2011 - 04/2011
2	CopperIBA 12/2011 - 04/2011
2	CollagenIBA 11/2011 - 05/2009
2	Superoxide Dismutase-1IBA 04/2011 - 07/2006
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2011 - 05/2009
2	Phosphotransferases (Kinase)IBA 12/2008 - 04/2005
2	beta-Globins (beta Globin)IBA 10/2003 - 07/2002
1	Phospholipases A2 (Phospholipase A2)IBA 01/2022
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2022
1	Messenger RNA (mRNA)IBA 01/2022
1	EnzymesIBA 01/2022
1	Arachidonic Acid (Vitamin F)IBA 01/2022
1	UbiquinoneIBA 11/2017
1	Proteoglycans (Proteoglycan)IBA 01/2017
1	AcetylglucosamineIBA 01/2017
1	Glycerol (Glycerine)FDA LinkGeneric 11/2015
1	Blood Glucose (Blood Sugar)IBA 11/2015
1	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 11/2015
1	LigandsIBA 03/2015
1	Ophthalmic Solutions (Eye Drops)IBA 01/2014
1	diquafosolIBA 01/2014
1	rebamipideIBA 11/2013
1	HDL CholesterolIBA 01/2013
1	Uric Acid (Urate)IBA 01/2013
1	IsoenzymesIBA 12/2012
1	Dinoprostone (PGE2)FDA Link 12/2012
1	8-Hydroxy-2'-DeoxyguanosineIBA 05/2012
1	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 05/2012
1	BilirubinIBA 01/2012
1	AntigensIBA 01/2012
1	Heme (Haem)IBA 01/2012
1	Advanced Glycation End ProductsIBA 12/2011
1	N(6)-carboxymethyllysine (carboxymethyllysine)IBA 12/2011
1	Insulin (Novolin)FDA Link 05/2011
1	Neuroprotective AgentsIBA 01/2011
1	NestinIBA 07/2010
1	D-Aspartic Acid (D Aspartate)IBA 06/2010
1	Rosmarinic AcidIBA 03/2010
1	SilymarinIBA 01/2010

Therapy/Procedure

1	Transplantation 11/2015
1	Nerve Block (Nerve Blocks) 06/2013
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 02/2011